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Thomas C. Bartee, Digital Computer Fundamentals McGraw Hill. The most respected.The Diagnostic Value of Indocyanine Green Angiography in Patients With Suspected Intraocular Tumors: A Systematic Review and Meta-Analysis.
To assess the diagnostic performance of indocyanine green angiography (ICGA) in patients with suspected intraocular tumors. A search of MEDLINE, EMBASE, and Cochrane databases was performed for studies evaluating ICGA in patients with intraocular tumors published between January 1, 2000, and January 1, 2019. A meta-analysis of included studies was performed. We identified 52 articles that fulfilled the criteria. Forty-three studies included suspected uveal melanoma (UM) and 29 studies included suspected intraocular lymphoma (IOL). Only 4 studies included suspected melanocytic conjunctival neoplasm (MCN), 6 included suspected choroidal hemangioma (CH), and 15 included suspected iris or ciliary body melanoma (IOCBM). The overall sensitivity of ICGA was 96% (95% confidence interval [CI], 91%-99%) and the specificity was 98% (95% CI, 97%-99%). The pooled sensitivity and specificity of ICGA were 97% (95% CI, 95%-98%) and 96% (95% CI, 93%-98%) in suspected UM. The sensitivity of ICGA was similar in suspected IOL (95%, 95% CI, 94%-97%) and MCN (98%, 95% CI, 98%-99%). However, the specificity of ICGA was higher in suspected IOL (98%, 95% CI, 97%-99%) than in suspected MCN (86%, 95% CI, 74%-92%). The pooled sensitivity of ICGA was 99% (95% CI, 97%-100%) in suspected CH, and the specificity was 99% (95% CI, 98 0b46394aab